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Updated: Jan 21, 2026

Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques
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Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques

Published on: April 22, 2010

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Cellular immune responses against cancer-germline genes in cancers

Sepideh Dashti, Zahra Taherian-Esfahani

    Human Antibodies
    |July 30, 2019
    PubMed
    Abstract

    Insights

    Cellular immune responses against cancer-germline genes are observed in patients with melanoma, lung, and breast cancers. These findings support the use of cancer-germline genes as targets for cancer immunotherapy.

    Area of Science:

    • Immunology
    • Oncology
    • Genetics

    Background:

    • Cancer-germline genes are expressed in normal tissues but abnormally in tumors.
    • Their expression suggests potential for inducing anti-cancer immune responses.
    • These genes are promising targets for cancer immunotherapy.

    Purpose of the Study:

    • To gather data on cellular immune responses to cancer-germline genes in cancer patients.
    • To evaluate cancer-germline genes as targets for cancer immunotherapy.

    Main Methods:

    • Literature search of PubMed/Medline.
    • Keywords included: cancer-germline antigen, cancer-testis antigen, CD4+ T cell, CD8+ T cell, and cancer.

    Main Results:

    • Approximately 40 cancer-germline genes elicit T cell responses in cancer patients.
    • Melanoma, lung, and breast cancers are frequently studied.
    • Identified epitopes can be utilized in cancer immunotherapy.

    Conclusions:

    • Cellular immune responses against cancer-germline genes confirm their suitability as therapeutic targets.
    • These genes represent a viable strategy for developing novel cancer immunotherapies.
    Keywords:
    Cancer-germline geneT cellcancercancer-testis antigenimmune response

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