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The association between hepatitis B, hepatitis C and systemic sclerosis: a cross-sectional study
Shmuel Tiosano1,2,3, Arnon D Cohen4,5, Howard Amital1,2,3
1Department of Medicine 'B'.
Current Opinion in Rheumatology
|July 30, 2019
Summary
Systemic sclerosis (SSc) is associated with chronic carriage of hepatitis B virus (HBV) and hepatitis C virus (HCV). SSc patients with HBV showed higher rates of end-stage renal disease requiring dialysis.
Area of Science:
- Rheumatology
- Hepatology
- Epidemiology
Background:
- Systemic sclerosis (SSc) is a complex autoimmune disease.
- Chronic viral hepatitis, including hepatitis B virus (HBV) and hepatitis C virus (HCV), affects millions globally.
- The potential association between SSc and viral hepatitis carriage requires further investigation.
Purpose of the Study:
- To investigate the association between systemic sclerosis (SSc) and chronic carriage of hepatitis B virus (HBV) and hepatitis C virus (HCV).
Main Methods:
- A cross-sectional study was conducted using the database of Clalit Health Services in Israel.
- The study included 2431 SSc patients and 12,710 age- and sex-matched controls.
- Multivariable logistic regression models were employed to analyze associations.
Main Results:
- HBV carriage was found in 1.56% of SSc patients versus 0.5% of controls (OR 2.97).
- HCV carriage was found in 1.23% of SSc patients versus 0.65% of controls (OR 1.73).
- Both HBV and HCV were associated with SSc, smoking, dialysis treatment, and low socioeconomic status. SSc patients with HBV had higher rates of end-stage renal disease requiring dialysis.
Conclusions:
- Chronic carriage of HBV and HCV is associated with SSc.
- Common immune mechanisms or therapeutic interventions may mediate this association.
- Further research is warranted to elucidate the underlying mechanisms and clinical implications.
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