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Updated: Jan 21, 2026

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Association of Statin Use With Kidney Damage and Function Among HIV-Infected Men

Simon B Ascher1,2, Rebecca Scherzer1, Arvind Nishtala3

  • 1Kidney Health Research Collaborative, Department of Medicine, San Francisco VA Health Care System, University of California, San Francisco, CA.

Journal of Acquired Immune Deficiency Syndromes (1999)
|July 30, 2019
PubMed

Insights

Statins did not prevent chronic kidney disease (CKD) in HIV-infected men, though they were linked to higher albumin-to-creatinine ratio (ACR) and a modest slowing of kidney function decline in those with proteinuria.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • Chronic kidney disease (CKD) is prevalent in HIV-infected individuals.
  • Statins possess cholesterol-lowering and pleiotropic properties that may mitigate CKD development and progression.

Purpose of the Study:

  • To investigate the association between statin use and kidney damage biomarkers in HIV-infected men.
  • To evaluate the impact of statins on the progression of kidney function and the incidence of CKD in this population.

Main Methods:

  • Cross-sectional and longitudinal analyses were performed on 850 HIV-infected men from the Multicenter AIDS Cohort Study.
  • Urine biomarkers of kidney damage and estimated glomerular filtration rate (eGFR) were assessed.
  • Inverse probability weighting was used to control for confounding factors related to statin use.

Main Results:

  • Statin use was associated with a 4.0% increase in baseline albumin-to-creatinine ratio (ACR) but not other urine biomarkers.
  • No overall association was found between statin use and annual eGFR decline.
  • Among participants with proteinuria, statin use showed a modest association with slower eGFR decline.

Conclusions:

  • Statin use was linked to elevated baseline ACR but not tubulointerstitial injury biomarkers.
  • A modest benefit on eGFR decline was observed only in HIV-infected men with pre-existing proteinuria.
  • Findings suggest a limited role for statins in reducing CKD risk among HIV-infected men, though confounding by indication is a consideration.
Abstract

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