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Updated: Jan 21, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

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POTENTIAL UTILITY OF FOVEAL MORPHOLOGY IN PRETERM INFANTS MEASURED USING HAND-HELD OPTICAL COHERENCE TOMOGRAPHY IN

Samira Anwar1,2, Mintu Nath3, Aarti Patel1

  • 1Ulverscroft Eye Unit, Robert Kilpatrick Clinical Sciences Building Leicester Royal Infirmary, University of Leicester, Leicester, United Kingdom.

Retina (Philadelphia, Pa.)
|July 30, 2019
PubMed

Insights

Foveal width, measured by optical coherence tomography, is a key indicator for retinopathy of prematurity screening. This finding may aid in managing preterm infants and assessing their visual development.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Medical Imaging

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of visual impairment in preterm infants.
  • Early detection and monitoring of ROP are crucial for effective management.
  • Hand-held optical coherence tomography (OCT) offers a non-invasive method for visualizing retinal structures.

Purpose of the Study:

  • To investigate dynamic foveal morphology in preterm infants with and without ROP.
  • To assess the relationship between foveal morphology, postmenstrual age, gestational age (GA), and birthweight (BW).
  • To evaluate the utility of hand-held OCT in characterizing foveal development in relation to ROP.

Main Methods:

  • Prospective observational study of 87 preterm infants (23-36 weeks GA).
  • Hand-held OCT imaging used to measure foveal width, area, depth, central foveal thickness, slope, and parafoveal retinal thickness.
  • Data analyzed adjusting for GA and BW.

Main Results:

  • Foveal width showed a significant correlation with ROP, independent of GA and BW.
  • Foveal area, depth, and slope correlated with prematurity severity (GA, BW).
  • Central foveal thickness and parafoveal retinal thickness correlated with GA but not BW.

Conclusions:

  • Foveal width is a potential biomarker for ROP screening using hand-held OCT.
  • Foveal morphology assessment during development may inform future management strategies for preterm infants.
  • Dynamic foveal changes can be monitored non-invasively in preterm infants.
Abstract

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