Chirality in amino acids beyond the C_α configuration

Based on a CSD search, a meta-analysis of 1179 structures of 19 natural amino acids H₃ NC_α H(R)C'(O)O and their derivatives H₃ NC_α H(R)C'(O)O(H/R/M), protonated, esterified, or coordinated at the carboxylic group, shows that the chirality chain with its two steps, established in the preceding paper for alanine, can be extended to natural amino acids. High diastereoselectivities are observed in the induction from the L configuration at C_α to the -ψ and +ψ conformations, which in turn distort the planar carboxylic group C_α C'(O_cis )O_trans to asymmetric flat tetrahedra, showing that the chirality chain is an integral part of natural amino acids.