Related Experiment Video
Updated: Jan 21, 2026

Laser Ablation of the Zebrafish Pronephros to Study Renal Epithelial Regeneration
Published on: August 29, 2011
Long-Term Outcomes of Patients With Low Grade Cystic Renal Epithelial Neoplasms
Mary E Westerman1, John C Cheville2, Christine M Lohse3
1Mayo Clinic Department of Urology, Rochester, MN.
Objective:
To report on the long-term oncologic outcomes of 3 subtypes of low grade cystic renal epithelial neoplasms-multilocular cystic neoplasm of low malignant potential (MCLMP), cystic clear cell RCC (ccRCC), and cystic clear cell papillary RCC (ccpRCC), following 2016 reorganization by the World Health Organization.
Materials And Methods:
A total of 3865 patients underwent radical or partial nephrectomy for unilateral, sporadic ccRCC between 1970 and 2010, of which 145 had previously been classified as cystic ccRCC. One genitourinary pathologist, blinded to outcome, rereviewed and reclassified the specimens by 2016 WHO criteria. Oncologic outcomes were estimated using the Kaplan-Meier method.
Results:
Of 145 specimens, 18 (12%) were classified as MCLMP, 95 (66%) cystic ccRCC, and 32 (22%) cystic ccpRCC. Those with MCLMP were more likely female (61% vs 29% vs 31%, P = .03) with larger tumors (median 4.6 cm vs 3.0 cm vs 2.3 cm, P = .02) compared to those with cystic ccRCC and cystic ccpRCC, respectively. Only 2% of cystic ccRCC had tumor necrosis or grade 3 nucleoli present. Median follow-up for survivors was 10.3 years (interquartile range 7.4-14.9). Overall, 1 MCLMP, 5 cystic ccRCC, and 4 ccpRCC recurred during follow-up. Ten- and 20-year cancer-specific survival was 100% across all subtypes.
Conclusion:
In a large cohort of patients previously classified as cystic ccRCC with pathologic rereview and long-term follow-up, we noted that MCLMP is the least common subtype of low grade cystic renal epithelial neoplasms. Regardless, all subtypes are associated with an excellent long-term prognosis following surgical resection.
More Related Videos
Related Concept Videos
Graded Potential
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
Cystic Fibrosis: Management
Sinus disease and chronic...
Predicting Reaction Outcomes
Types of Aggregate Grading
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
Outcomes of Glycolysis
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...

