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Chagas disease in the Bolivian Chaco: Persistent transmission indicated by childhood seroscreening study

Thomas Hopkins1, Raquel Gonçalves2, Janet Mamani3

  • 1Warwick Medical School, The University of Warwick, Coventry, UK.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|July 30, 2019
PubMed

Insights

Persistent Trypanosoma cruzi infection transmission was confirmed in Bolivian Chaco children. School-based screening proved practical for detecting Chagas disease, highlighting ongoing public health challenges.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • High prevalence of Trypanosoma cruzi infection in the Bolivian Chaco.
  • Focus on screening children in a rural community.
  • Estimation of the force of infection (FOI).

Purpose of the Study:

  • To screen children for Trypanosoma cruzi infection.
  • To estimate the force of infection (FOI).
  • To assess the effectiveness of school-based screening.

Main Methods:

  • Screening of 423 children using the Chagas Detect Plus (CDP) rapid test.
  • Confirmation of positive cases with indirect haemagglutination assay (IHA) and Wiener Recombinante v3.0 ELISA.
  • Utilizing a catalytic model to estimate FOI.

Main Results:

  • Confirmed seroprevalence of 0.22, increasing with age.
  • Mean age of seropositive children was 13 years.
  • Rapid test specificity was 91.9%; annual incidence was estimated at 0.021.

Conclusions:

  • Demonstrated persistent transmission of Trypanosoma cruzi infection.
  • Indicated continuing high infection levels in the Bolivian Chaco.
  • Highlighted the practicality and effectiveness of school-based screening programs.
Abstract

Keywords:
Bolivian ChacoChagas diseaseScreening studyT. cruziTrypanosoma cruzi

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