Effects of increasing serotonergic receptor activity in brain on prostagladin E1-induced fever in rabbits

In rabbits, increasing serotonergic receptor activity or funtional serotonin in brain with either the inhibitors of serotonin reuptake (e.g. fluoxetine and chlorimipramine) or the serotonin precursor 5-hydroxytryptophan in combination with the peripheral decarboxylase inhibitor benserazide, greatly reduced the fever induced by intraventricular prostaglandin E1. The data indicate the brain serotonin plays a role in the elaboration or modulation of the prostaglandin E1-induced fever.