Childhood maltreatment and treatment outcome in psychotic disorders: a systematic review and meta-analysis

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S Thomas1, M Höfler1, I Schäfer2,3

  • 1Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.

Acta Psychiatrica Scandinavica
|July 30, 2019
PubMed

Insights

Childhood maltreatment (CM) is linked to worse treatment outcomes in psychotic disorders. Identifying patients with CM may help improve their recovery and functioning.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • Childhood maltreatment (CM) is a significant factor in the development and progression of psychotic disorders.
  • CM is associated with specific characteristics that may influence treatment effectiveness.

Purpose of the Study:

  • To systematically review and conduct a meta-analysis on the association between childhood maltreatment and treatment outcomes in patients with psychotic disorders.

Main Methods:

  • A systematic review and meta-analysis were performed.
  • Included were twelve treatment results from seven studies encompassing 636 patients with an average treatment duration of 59.2 weeks.

Main Results:

  • Childhood maltreatment was associated with poorer treatment outcomes in psychotic disorders (OR = 1.51, 95% CI = [1.08, 2.10]).
  • The negative association between CM and treatment outcome may intensify with longer illness duration and increasing age.
  • This association appears to be more pronounced in schizophrenia samples.

Conclusions:

  • Research on childhood maltreatment's impact on treatment outcomes in psychotic disorders is limited.
  • This meta-analysis provides evidence suggesting poorer treatment response in patients with a history of CM.
  • Further research confirming this association could lead to improved identification and tailored treatment strategies for patients with CM, potentially enhancing treatment outcomes.
Abstract

Keywords:
child abusemeta-analysispsychotic disordersschizophreniatreatment outcome

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