Related Experiment Video
Updated: Jan 21, 2026

Sensitivity Enhancement of Soft Capacitive Pressure Sensors Using a Solvent Evaporation-Based Porosity Control Technique
Published on: March 24, 2023
Au@SiO2@RuDS nanocomposite based plasmon-enhanced electrochemiluminescence sensor for the highly sensitive detection
Nian Cao1, Peng Zeng1, Faqiong Zhao1
1Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, Hubei Province, PR China.
Abstract:
A novel plasmon enhanced electrochemiluminescence (ECL) sensor was fabricated for the highly sensitive detection of glutathione (GSH). First, Au nanoparticles (AuNPs) were coated with silica dioxide to prevent the direct contact of AuNPs and luminophore Ru(bpy)32+; then Ru(bpy)32+-containing silica layer (RuDS) was allowed to grow onto the obtained Au@SiO2. Owing to the high luminescence efficiency of RuDS and the surface plasmon resonance of AuNPs, the nanocomposite Au@SiO2@RuDS exhibited large ECL signal. As free radical scavenger, GSH could react with tri-n-propylamine radical (i.e. TPA+•) and effectively suppress the excitation of Ru(bpy)32+, thus made the ECL signal significantly decrease. By using Nafion as immobilization reagent, the resulting Au@SiO2@RuDS/GCE sensor showed wide linear response ranges (1.0 fM-1.0 nM and 1.0 nM-1.0 μM) and low detection limit (0.5 fM, S/N=3) for GSH. In addition, it had excellent stability, repeatability and reproducibility. The sensor was applied to the detection of GSH in human serum samples and satisfactory results were achieved.
More Related Videos
Related Concept Videos
Self-Evaluation: Self-Enhancement and Self-Verification
Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
Bioavailability Enhancement: Drug Solubility Enhancement
Bioavailability Enhancement: Drug Permeability Enhancement
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Sensitivity, Specificity, and Predicted Value
Sensitivity is the...

