Related Experiment Video

Updated: Jan 21, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

14.1K

Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies

Yi Xiao1,2, David Meierhofer3

  • 1Max Planck Institute for Molecular Genetics, Ihnestraße 63-73, 14195 Berlin, Germany.

International Journal of Molecular Sciences
|July 31, 2019
PubMed

Insights

Renal cell carcinoma (RCC) exhibits elevated glutathione (GSH), a reactive oxygen species (ROS) scavenger. Targeting GSH metabolism presents a promising therapeutic strategy for RCC treatment.

Area of Science:

  • Oncology
  • Biochemistry
  • Metabolism

Background:

  • Elevated glutathione (GSH) levels are a hallmark of renal cell carcinoma (RCC), crucial for malignancy survival.
  • Increased GSH counteracts reactive oxygen species (ROS), supporting cancer cell viability and growth.

Purpose of the Study:

  • To review current knowledge on three main RCC subtypes (ccRCC, pRCC, chRCC).
  • To highlight the influence of RCC subtypes on GSH metabolism.
  • To discuss GSH manipulation as a potential RCC treatment strategy.

Main Methods:

  • Literature review of genetic, transcriptomic, proteomic, and metabolomic data for RCC subtypes.
  • Analysis of the interplay between RCC subtypes and GSH metabolism.
  • Discussion of therapeutic strategies targeting GSH.

Main Results:

  • RCC subtypes (ccRCC, pRCC, chRCC) exhibit distinct molecular profiles.
  • GSH metabolism is significantly altered across RCC subtypes.
  • Interactions between cancer genetics and GSH pathways are evident.

Conclusions:

  • Understanding subtype-specific GSH alterations is key.
  • Targeting GSH metabolism offers a potential therapeutic avenue for RCC.
  • Further research into GSH-modulating agents is warranted for RCC treatment.
Keywords:
Renal cell carcinoma (RCC)cancer therapychromophobe RCCclear cell RCCglutathione (GSH) metabolismpapillary RCCreactive oxygen species (ROS)

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