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[Research progress of deubiquitinating enzyme CYLD to regulate liver-related diseases]

X Yang1, D J An, C C Gao

  • 1Department of Medical Genetics and Developmental Biology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|July 31, 2019
PubMed

Insights

The Cylindromatosis (CYLD) gene, a tumor suppressor, encodes a deubiquitinating enzyme. CYLD negatively regulates liver disease progression by removing K63 ubiquitin chains and impacting key signaling pathways.

Area of Science:

  • Molecular biology
  • Oncology
  • Hepatology

Background:

  • The Cylindromatosis (CYLD) gene functions as a tumor suppressor.
  • CYLD encodes a deubiquitinating enzyme critical for cellular regulation.
  • Mutations in CYLD are linked to tumor development.

Purpose of the Study:

  • To review recent research on the CYLD protein.
  • To highlight CYLD's role in liver-related diseases.
  • To elucidate CYLD's deubiquitinating functions.

Main Methods:

  • Literature review of recent studies on CYLD.
  • Analysis of CYLD's enzymatic activity in removing K63-linked ubiquitin chains.
  • Examination of CYLD's involvement in NF-κB, JNK, and Wnt signaling pathways.

Main Results:

  • CYLD deubiquitinating enzyme removes K63 ubiquitin chains from substrate proteins.
  • CYLD modulates crucial signaling pathways including NF-κB, JNK, and Wnt.
  • Recent findings emphasize CYLD's negative regulatory role in liver disease progression.

Conclusions:

  • CYLD is a key deubiquitinating enzyme with tumor suppressor functions.
  • CYLD plays a significant role in regulating cellular signaling.
  • CYLD emerges as a critical factor in controlling the advancement of liver diseases.
Keywords:
Deubiquitinating enzymeGene, cylindromatosisLiver diseaseUbiquitination

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