[Research progress on the Yes-associated proteins parameters and its mechanism of action in liver diseases]
1Southern Medical University School of Pharmaceutical Science; Department of Infectious Diseases and Hepatology Unit, Southern Medical University Nanfang Hospital; Southern Medical University Biomedical Research Center, Guangzhou 510515, China.
Abstract:
The transcriptional coactivator Yes-associated protein (YAP) is involved in the regulation of various cellular physiological activities and plays an important role in controlling the size of tissues and organs for maintaining the homeostasis. YAP not only affects the transcriptional expression of its downstream target genes, but also interacts with multiple signaling pathways to form complex regulatory networks to perform specific biological functions. In addition to Hippo signaling pathway mediated protein phosphorylation, the regulatory mechanisms of YAP activity also takes part in multiple fields. YAP activity alteration can affect the morphological characteristics and physiological functions of liver tissue, and participate in the occurrence and development of liver diseases, such as liver fibrosis and primary liver cancer. This paper mainly discusses the close relationship between YAP and liver pathophysiology, in order to provide reference for further exploring its potential application in molecular targeted therapy of liver diseases.
Insights
Yes-associated protein (YAP) regulates tissue size and homeostasis. YAP
Area of Science:
- Molecular Biology
- Cell Biology
- Physiology
Background:
- Yes-associated protein (YAP) is a transcriptional coactivator.
- YAP regulates cellular physiological activities and tissue/organ size.
- YAP integrates multiple signaling pathways for biological functions.
Purpose of the Study:
- To discuss the relationship between YAP and liver pathophysiology.
- To provide reference for YAP's potential application in liver disease molecular targeted therapy.
Main Methods:
- Literature review on YAP's role in cellular physiology and liver diseases.
- Analysis of YAP's interaction with signaling pathways and its impact on liver tissue.
Main Results:
- YAP activity alterations affect liver tissue morphology and function.
- YAP is implicated in the development of liver fibrosis and primary liver cancer.
Conclusions:
- YAP plays a critical role in liver pathophysiology.
- Understanding YAP's mechanisms may lead to novel molecular targeted therapies for liver diseases.
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