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[Relationship between selenium and the risk for oral cancer: a case-control study]
1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
Summary
Higher selenium levels are linked to a lower risk of oral cancer. This study found selenium interacts with lifestyle factors like diet and substance use, suggesting protective effects against oral cancer.
Area of Science:
- Nutritional Biochemistry
- Oncology
- Epidemiology
Background:
- Oral cancer remains a significant global health concern.
- Understanding the role of micronutrients like selenium in cancer prevention is crucial.
Purpose of the Study:
- To investigate the association between serum selenium levels and the risk of developing primary oral cancer.
- To explore potential interactions between selenium status and lifestyle factors (smoking, alcohol, diet) in oral cancer risk.
Main Methods:
- A case-control study involving 325 oral cancer cases and 650 controls.
- Unconditional logistic regression and stratification analyses were employed.
- Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated.
Main Results:
- Serum selenium levels were significantly lower in oral cancer cases (112.42 μg/L) compared to controls (164.85 μg/L).
- A negative correlation was observed between serum selenium and oral cancer risk, independent of smoking, drinking, fruit, and fish intake.
- Significant interactions were identified between serum selenium and these lifestyle factors.
Conclusions:
- Elevated serum selenium levels appear to be protective against oral cancer incidence.
- Serum selenium status interacts with smoking, alcohol consumption, and dietary habits (fruit and fish intake).
- Reducing tobacco and alcohol use, alongside increasing fruit and fish consumption, may mitigate oral cancer risk.
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