Related Experiment Video

Updated: Jan 21, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

19.8K

MicroRNAs in acquired sensorineural hearing loss

H H R Chen1, P Wijesinghe1,2, D A Nunez1,2

  • 1Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, Canada.

The Journal of Laryngology and Otology
|July 31, 2019
PubMed
Abstract

Insights

MicroRNAs play a role in age-related hearing loss (presbyacusis) by altering cellular activity and inner-ear balance. Their role in sudden hearing loss requires further investigation.

Area of Science:

  • Molecular Biology
  • Otolaryngology
  • Genetics

Background:

  • Presbyacusis (age-related hearing loss) and sudden sensorineural hearing loss are significant auditory impairments.
  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and are implicated in various cellular processes.

Purpose of the Study:

  • To review the current literature on the role of microRNAs in the pathogenesis of presbyacusis and sudden sensorineural hearing loss.

Main Methods:

  • A systematic literature search was conducted in Medline, PubMed, Web of Science, and Embase databases for English-language studies published between 2000 and 2017.
  • Nine high-quality studies were included in the review after applying inclusion criteria.
  • The National Institutes of Health quality assessment tool was used to evaluate the evidence quality.

Main Results:

  • In presbyacusis, upregulated miRNAs are associated with pro-apoptotic and autophagy pathways, while downregulated miRNAs are linked to proliferative and differentiation pathways.
  • A shift in miRNA expression may lead to reduced cellular activity and impaired inner-ear homeostasis, contributing to presbyacusis.
  • The evidence for a direct etiological role of miRNAs in sudden hearing loss is currently limited.

Conclusions:

  • Altered microRNA expression profiles are implicated in the pathogenesis of age-related hearing loss.
  • Further research is needed to elucidate the specific mechanisms and potential therapeutic targets of miRNAs in both presbyacusis and sudden sensorineural hearing loss.
Keywords:
MiRNA-MRNA InteractionsMicroRNAsPresbycusisSensorineural Hearing Loss

More Related Videos

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation03:49

Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation

Published on: October 11, 2024

1.2K
Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

2.8K

Related Concept Videos

Hearing01:31

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
56.7K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.8K
Line Loss01:10

Line Loss

The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
517
Reducing Line Loss01:18

Reducing Line Loss

In a three-phase circuit, line loss is an indicator of energy dissipated as heat due to the resistance of transmission lines. To address this, incorporating transformers into the system—a step-up transformer at the source and a step-down transformer at the load—is a strategic solution. Two three-phase transformers are introduced to improve this.
With a step-up transformer at the source, the voltage is increased, thereby reducing the current in the transmission lines since power loss in...
370
Major Losses in Pipes01:28

Major Losses in Pipes

When a fluid flows through a pipe, it experiences energy losses due to frictional resistance along the pipe walls, known as major losses. These energy losses result in a pressure drop, which varies based on the flow conditions — whether laminar or turbulent — and the specific physical properties of the fluid and pipe.
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
1.9K