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Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants
Published on: January 26, 2019
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Altered Functional Brain Network Integration, Segregation, and Modularity in Infants Born Very Preterm at
Marine Bouyssi-Kobar1, Josepheen De Asis-Cruz2, Jonathan Murnick2
1The Developing Brain Research Laboratory, Department of Diagnostic Imaging and Radiology, Children's National Health System, Washington, DC; Institute for Biomedical Sciences, George Washington University, Washington, DC.
The Journal of Pediatrics
|July 31, 2019
Summary
Infants born very preterm show altered brain network organization compared to full-term infants. Clinical factors like respiratory illness impact brain network efficiency, suggesting disrupted development.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Brain Imaging
Background:
- Infants born very preterm face risks for neurodevelopmental impairments.
- Understanding brain functional network organization is crucial for identifying early biomarkers of altered neurodevelopment.
Purpose of the Study:
- To investigate the functional brain network organization in very preterm infants at term-equivalent age.
- To correlate observed network alterations with clinical risk factors for poor neurological outcomes.
Main Methods:
- Resting-state functional magnetic resonance imaging (fMRI) was used in 66 very preterm and 66 full-term infants.
- Graph theory analysis assessed network properties like integration, segregation, and modularity across 93 brain regions.
Main Results:
- Very preterm infants exhibited less segregated and integrated resting-state networks compared to controls.
- Chronic respiratory illness was linked to reduced global efficiency and increased path lengths.
- Connectivity was decreased in most modules but increased in the occipital/visual cortex module in preterm infants.
Conclusions:
- Altered functional brain network organization in very preterm infants suggests disrupted maturational processes due to early ex utero environmental exposure.
- These findings highlight potential targets for early intervention to improve neurodevelopmental outcomes.
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