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Updated: Jan 21, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

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Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation

Sarah E Webb1, Jeffrey J Kelu1, Andrew L Miller1

  • 1Division of Life Science & State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology (HKUST), Clearwater Bay, Hong Kong, PRC.

Cold Spring Harbor Perspectives in Biology
|July 31, 2019
PubMed

Insights

Nicotinic acid adenine dinucleotide phosphate (NAADP) and two-pore channels (TPCs) regulate calcium signaling essential for early embryonic development and cell differentiation. This review highlights TPC2

Area of Science:

  • Cellular Biology
  • Developmental Biology
  • Physiology

Background:

  • The nicotinic acid adenine dinucleotide phosphate (NAADP)/two-pore channel (TPC)/Ca2+ signaling pathway is implicated in diverse cellular functions.
  • TPCs are linked to various diseases and play critical roles in embryogenesis and cell differentiation.

Purpose of the Study:

  • To review the role of NAADP/TPC/Ca2+ signaling in early embryonic development and cellular differentiation.
  • To highlight the conserved features of TPC-mediated Ca2+ signaling across different cell types and developmental processes.

Main Methods:

  • Literature review focusing on studies of NAADP/TPC/Ca2+ signaling.
  • Emphasis on TPC2 function in zebrafish neuromuscular development.
  • Analysis of TPC2 role in osteoclast, endothelial, and keratinocyte differentiation.

Main Results:

  • NAADP/TPC/Ca2+ signaling is crucial for early embryonic development.
  • TPC2 plays a significant role in the maturation of neuromuscular activity in zebrafish.
  • TPC2 is involved in the differentiation of osteoclasts, endothelial cells, and keratinocytes.

Conclusions:

  • TPC-mediated Ca2+ signaling is a conserved mechanism vital for embryonic development and cellular differentiation.
  • Understanding TPC function offers insights into developmental processes and potential therapeutic targets for related diseases.

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