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Isolation and Transplantation of Hematopoietic Stem Cells HSCs
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Vitiligo following stem-cell transplant.

Alessio Totani1, Hossam Amin2, Stephen Bacchi3

  • 1Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia. a1689307@student.adelaide.edu.au.

Bone Marrow Transplantation
|July 31, 2019
PubMed
Summary

Vitiligo, a skin depigmentation disorder, appears more frequently in patients after haematopoietic stem cell transplantation (HSCT). Further research is needed to clarify the link between HSCT, vitiligo, and graft-versus-host disease (GVHD).

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Area of Science:

  • Dermatology
  • Immunology
  • Hematology

Background:

  • Vitiligo is an autoimmune skin condition causing depigmentation due to melanocyte destruction.
  • Associations between vitiligo and other autoimmune diseases are known.
  • Haematopoietic stem cell transplantation (HSCT) is used for hematological conditions and may trigger autoimmune responses.

Observation:

  • A literature review was conducted on studies reporting vitiligo incidence post-HSCT.
  • Databases searched included Pubmed, EMBASE, and SCOPUS up to May 2017.
  • The review included 38 cases from 28 reports and 9 cohort studies.

Findings:

  • The incidence of vitiligo is higher in patients who have undergone HSCT compared to the general population.
  • Potential connections between vitiligo and graft-versus-host disease (GVHD) following HSCT were investigated.
  • Existing studies are predominantly single-case reports with inconsistencies.

Implications:

  • The findings suggest a potential link between HSCT and the development of vitiligo.
  • Further research with consistent patient/donor profiling is necessary to understand this association.
  • Understanding the relationship may inform management strategies for HSCT recipients and autoimmune disease patients.