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Asthma Phenotypes as a Guide for Current and Future Biologic Therapies.
Daniel Hamilton1, Heather Lehman2
1SUNY Upstate Medical University College of Medicine, Syracuse, NY, USA.
Clinical Reviews in Allergy & Immunology
|July 31, 2019
Summary
Asthma is a complex disease with various underlying causes. Personalized treatment using targeted biologic therapies, guided by specific biomarkers, offers a more effective approach than traditional methods.
Area of Science:
- Pulmonology
- Immunology
- Personalized Medicine
Background:
- Asthma is increasingly understood as a heterogeneous disease with diverse pathophysiologies.
- A shift from generalized to individualized treatment approaches is evident in asthma management.
- Biologic therapies offer targeted treatment options for specific asthma subtypes.
Purpose of the Study:
- To review major asthma phenotypes.
- To explore the evidence supporting biologic therapies for each phenotype.
- To discuss the role of biomarkers in guiding personalized asthma treatment.
Main Methods:
- Review of current scientific literature on asthma phenotypes and biologic therapies.
- Analysis of existing biomarkers and their utility in clinical decision-making.
- Exploration of ongoing research for novel biomarker identification.
Main Results:
- Asthma exhibits distinct phenotypes driven by various cellular and environmental factors.
- Current biomarkers aid in biologic selection but lack specificity for precise phenotyping.
- Biomarker research is crucial for optimizing targeted biologic therapies.
Conclusions:
- Identifying asthma phenotypes is key to predicting disease trajectory and treatment response.
- Personalized medicine, utilizing targeted biologics based on phenotype and biomarkers, represents the future of asthma care.
- Continued research into novel biomarkers is essential for advancing precision asthma treatment.
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