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Sensational MicroRNAs: Neurosensory Roles of the MicroRNA-183 Family

Samantha A Banks1, Marsha L Pierce2, Garrett A Soukup3

  • 1Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, 68178, USA.

Molecular Neurobiology
|July 31, 2019
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are vital for nervous system functions. The miR-183 family is crucial for sensory neuron development and function, impacting processes from hearing to memory.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are short noncoding RNAs regulating gene expression.
  • Dysregulation of miRNAs is linked to various diseases.
  • The miR-183 family, including miR-183, miR-96, and miR-182, is conserved and specifically expressed in sensory cells.

Purpose of the Study:

  • To provide an overview of the roles of miR-183 family members in the normal biology of the nervous system.
  • To highlight the importance of these miRNAs in sensory perception and neural function.

Main Methods:

  • Literature review of existing research on miR-183 family function.
  • Analysis of studies investigating miRNA roles in sensory neurons and epithelial cells.

Main Results:

  • The miR-183 family plays critical roles in mechanoreception (auditory, vestibular), electroreception, chemoreception, and photoreception.
  • These miRNAs are involved in sensory ganglia, pain perception, circadian rhythms, and memory formation.

Conclusions:

  • The miR-183 family is essential for the proper development and function of the nervous system, particularly in sensory processing.
  • Further research is needed to fully elucidate the complex roles of these miRNAs in neural biology and disease.
Keywords:
ChemoreceptionCircadian rhythmMechanoreceptionMemoryMicroRNA-183 familyPhotoreception

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