Related Experiment Video
Updated: Jan 21, 2026
06:36
Establishment of Central Cord Syndrome Model in C57BL/6J Mouse
Published on: September 8, 2023
1.1K
Dieulafoy lesions and PHACE syndrome
Lukas Kieswetter1, Thomas D Walters2, Irene Lara-Corrales3
1Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada.
Pediatric Dermatology
|July 31, 2019
Summary
Dieulafoy
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Vascular Malformations
Background:
- Dieulafoy's lesions (DL) are rare causes of gastrointestinal bleeding, typically seen in adults.
- Pediatric DLs are exceptionally uncommon, presenting diagnostic and therapeutic challenges.
Observation:
- A 9-year-old girl with PHACE syndrome (posterior fossa brain malformations, hemangiomas, arterial lesions, cardiac abnormalities, eye abnormalities) presented with jejunal DLs.
- The patient experienced significant gastrointestinal bleeding attributed to these multiple jejunal lesions.
Findings:
- Multiple jejunal Dieulafoy's lesions were identified as the source of bleeding.
- Rapamycin was utilized for the treatment of pediatric DLs, marking its first described use in this context.
Implications:
- This case highlights the rare occurrence of DLs in children, particularly those with complex syndromes like PHACE.
- The successful use of rapamycin suggests a potential novel therapeutic avenue for pediatric DLs, warranting further investigation.
Related Concept Videos
01:24Nephrotic Syndrome I : Introduction
522
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
522
01:30Acute Coronary Syndrome I: Introduction
868
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
868
01:17Irritable Bowel Syndrome I: Introduction
939
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
939
01:26Acute Coronary Syndrome V: Nursing Management
283
Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
283
01:26Nephrotic Syndrome II : Assessment and Medical Management
212
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
212
01:24Nephrotic Syndrome III : Nursing Management
289
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
289