Dieulafoy lesions and PHACE syndrome
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Updated: Jan 21, 2026

Establishment of Central Cord Syndrome Model in C57BL/6J Mouse
Published on: September 8, 2023
Lukas Kieswetter1, Thomas D Walters2, Irene Lara-Corrales3
1Department of Paediatrics, McMaster University, Hamilton, Ontario, Canada.
Abstract:
Dieulafoy's lesion (DL) is a small gastrointestinal (GI) mucosal erosion due to an abnormally large caliber and persistent submucosal arteriole. Typically occurring in adults, they are an extremely rare cause of GI bleeding in pediatrics. We report a case of multiple jejunal DLs in a 9-year-old girl with posterior fossa brain malformations, hemangiomas, arterial lesions, cardiac abnormalities, eye abnormalities (PHACE) syndrome, and the first described use of rapamycin in the treatment of pediatric DLs.
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