Related Experiment Video
Updated: Jan 21, 2026
The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies
Published on: August 25, 2023
Methodological decisions influence the identification of potential core outcomes in studies related to
Jmn Duffy1,2, M Hirsch2, S Ziebland1
1Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Objective:
To quantify the effect of different methodological decisions on the identification of potential core outcomes to inform the development of recommendations for future core coutcome set developers.
Design:
Mixed methods study.
Setting:
A core outcome set for pre-eclampsia was used as an exemplar.
Sample:
A long list of potential core outcomes was developed by undertaking a systematic review of pre-eclampsia trials and performing a thematic analysis of in-depth patient interviews.
Methods:
Specific methods used to generate long lists of potential core outcomes were evaluated.
Results:
Different methodological decisions had a substantial impact on the identification of potential core outcomes. Extracting outcomes from published pre-eclampsia trials was an effective way of identifying 48 maternal, eight fetal, 25 neonatal outcomes, and eight patient-reported outcomes. Limiting the extraction of outcomes to primary outcomes or outcomes commonly reported in pre-eclampsia trials reduced the number and diversity of potential core outcomes identified. Thematic analysis of in-depth patient interviews ensured an additional five patient reported outcomes and six outcomes related to future child health were identified.
Conclusions:
Future core outcome set developers should use quantitative and qualitative methods when developing a long list of potential core outcomes. TWEETABLE ABSTRACT: @OfficialNIHR research published in @BJOGtweets informs new recommendations for future @coreoutcomes developers.
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