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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Retinal vessel phenotype in patients with primary open-angle glaucoma
Christophe Chiquet1,2, Olivier Gavard1,2, Louis Arnould3
1Department of Ophthalmology, University Hospital of Grenoble, Grenoble, France.
Acta Ophthalmologica
|July 31, 2019
Summary
Primary open-angle glaucoma (POAG) is linked to narrower retinal arteries and veins, and altered fractal dimensions. Further research is needed to understand the CRAE and RNFL thickness connection.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Retinal vascular changes are increasingly recognized as potential indicators of glaucoma progression.
- Quantitative analysis of retinal vasculature may offer new insights into POAG pathophysiology.
Purpose of the Study:
- To investigate the characteristics of retinal vessels in primary open-angle glaucoma (POAG) patients.
- To compare central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), tortuosity, and fractal dimension (FD) between POAG subjects and healthy controls.
- To explore the relationship between these vascular parameters and glaucoma severity indicators.
Main Methods:
- A prospective case-control multicentre study involving 61 POAG patients and 61 matched controls.
- Fundus images were analyzed using VAMPIRE software to measure CRAE, CRVE, arteriole-to-venule ratio, FD, and tortuosity.
- POAG patients also underwent visual field testing and optical coherence tomography (OCT) for retinal nerve fibre layer (RNFL) thickness assessment.
Main Results:
- POAG patients exhibited significantly lower mean CRAE and CRVE compared to controls.
- Fractal dimension parameters were also significantly lower in the POAG group.
- A significant positive correlation was observed between CRAE and RNFL thickness, but VAMPIRE parameters did not correlate with visual field indices.
Conclusions:
- Primary open-angle glaucoma (POAG) is associated with significant alterations in retinal vascular morphology, including vessel narrowing and reduced fractal dimension.
- The findings suggest that retinal vessel analysis could be a valuable tool in understanding POAG.
- Further investigation is warranted to elucidate the link between CRAE and RNFL thickness in POAG.
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