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Highly Substituted Medium-Sized Ring-Fused Azocinoquinoline Scaffolds by Post-Ugi-4CR Reductive Carbopalladation
Helya Janatian Ghazvini1, Thomas J J Müller2, Frank Rominger3
1Peptide Chemistry Research Center , K. N. Toosi University of Technology , P.O. Box 15875-4416, Tehran , Iran.
Abstract:
A concise synthesis of quinoline-fused eight-membered rings from simple starting materials is described. Reductive cyclo-carbopalladation of suitable Ugi-4CR substrates as a key step leads to the regio- and diastereoselective formation of 1,2-dihydroazocino[4,3-b]quinolin-3-ones under mild reaction conditions with good yields in short reaction time.
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