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Tamoxifen-induced vasculitis.

Utkarsha Kulkarni1, Veena Nayak1, Mukhyaprana M Prabhu2

  • 1Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Karnataka, India.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|July 31, 2019
PubMed
Summary
This summary is machine-generated.

Tamoxifen, a common breast cancer drug, can rarely cause vasculitis. This case highlights the need for vigilant monitoring of this severe side effect in pre-menopausal women.

Keywords:
Breast cancerchemotherapytamoxifenvasculitis

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Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Tamoxifen is a widely prescribed selective estrogen receptor modulator for breast cancer treatment.
  • While known for adverse effects like endometrial cancer and thrombosis, its link to vasculitis is infrequently reported.

Observation:

  • A 45-year-old pre-menopausal woman developed vasculitis six months after initiating tamoxifen therapy post-mastectomy.
  • The condition was confirmed via immunofluorescence, indicating tamoxifen-induced vasculitis.

Findings:

  • Dapsone provided temporary symptom relief, but vasculitis recurred upon its discontinuation.
  • The patient's ongoing vasculitis is attributed to the inability to cease tamoxifen treatment.

Implications:

  • This case underscores the rare but severe risk of cutaneous vasculitis associated with tamoxifen.
  • Emphasizes the critical need for strict adverse event monitoring and further research into alternative breast cancer agents for pre-menopausal women.