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Hypoplastic acute myeloid leukemia in an elderly patient. A long-term partial remission with low-dose prednisone and

Anwarul Islam1

  • 1Division of Hematology/Oncology, Department of Medicine Buffalo General Hospital Buffalo New York.

Clinical Case Reports
|July 31, 2019
PubMed

Insights

Hypoplastic acute myeloid leukemia (AML) is rare in the elderly. A combination of low-dose prednisone and G-CSF showed promising results in one patient, suggesting a potential new treatment option.

Area of Science:

  • Hematology
  • Oncology

Background:

  • Hypoplastic acute myeloid leukemia (AML) is a rare subtype, primarily affecting elderly individuals.
  • This condition represents 5%-7% of de novo AML cases.
  • Patients with hypoplastic AML face a poor prognosis and lack established treatment protocols.

Observation:

  • An elderly patient with hypoplastic AML was treated.
  • The treatment involved low-dose prednisone and granulocyte-colony stimulating factor (G-CSF).

Findings:

  • The patient experienced good results with this treatment regimen.
  • This combination therapy demonstrated efficacy in managing hypoplastic AML.

Implications:

  • Low-dose prednisone and G-CSF may offer a viable alternative to supportive care.
  • This approach could be a less aggressive option compared to chemotherapy for elderly patients.
Keywords:
G‐CSFelderly patientsfilgrastimhypoplastic acute myeloid leukemiamyeloid malignanciesprednisone

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