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Area of Science:

  • Biomedical Optics
  • Nanotechnology
  • Materials Science

Background:

  • Third harmonic generation (THG) microscopy offers label-free imaging capabilities.
  • Developing activatable probes enhances spatiotemporal control in THG imaging.
  • Nanoparticle-based systems are promising for targeted delivery and imaging.

Purpose of the Study:

  • To introduce a new class of activatable THG imaging probes.
  • To demonstrate precise spatiotemporal control over probe activation using non-linear excitation.
  • To explore potential applications in biological imaging and targeted drug delivery.

Main Methods:

  • Synthesized lipid-coated perfluorocarbon nanodroplets with embedded visible chromophores.
  • Utilized two-photon absorption of near-infrared (NIR) light to induce droplet phase transition.
  • Leveraged the resulting microbubbles as a source of THG signal.

Main Results:

  • Demonstrated successful activation of THG signal upon NIR light exposure.
  • Observed phase transition of nanodroplets to microbubbles, creating a refractive index mismatch.
  • Confirmed the potential for THG signal generation from these activated nanodroplets.

Conclusions:

  • Developed novel, activatable THG imaging probes with precise spatiotemporal control.
  • These probes show significant potential as agents for advanced biological imaging.
  • The platform supports "on-demand" compound delivery monitored by THG imaging.