Related Experiment Video
Updated: Jan 21, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
A Study Protocol for Development and Validation of a Clinical Prediction Model for Frailty (ModulEn): a new European
J Apóstolo1,2, E Bobrowicz-Campos2, T Moreno-Casbas3,4
1Nursing School of Coimbra, Coimbra, Portugal.
This study introduces the ModulEn protocol to develop a predictive model for age-related frailty using wearable technology. Early detection through continuous monitoring can help manage the challenges of demographic aging.
Area of Science:
- Gerontology
- Digital Health
- Preventive Medicine
Background:
- Growing need for early detection of age-related frailty.
- Technological solutions are crucial for sustainable healthcare systems facing demographic aging.
- Current methods for frailty assessment require enhancement.
Purpose of the Study:
- To develop and validate a predictive model for frailty in older adults.
- To evaluate the utility of continuous monitoring via electronic devices for frailty assessment.
- To explore the associations between monitored health data and frailty components.
Main Methods:
- Protocol for the ModulEn study involving community-recruited older adults (65-80 years).
- Utilizing the ACM Kronowise® 2.0 device for continuous monitoring of circadian health, physical activity, sleep, and eating habits over 7-10 days.
- Combining device data with questionnaire-based assessments of frailty, user experience, and satisfaction.
Main Results:
- The study protocol is established for developing a predictive frailty model.
- Data integration from continuous monitoring and questionnaires will identify key frailty predictors.
- Validation of the predictive model is planned.
Conclusions:
- Findings may lead to validated tools for timely frailty prevention.
- Potential for significant reduction in frailty burden in Europe.
- Technological integration in healthcare can address challenges of an aging population.
More Related Videos
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
04:00Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
Published on: July 26, 2024
Related Concept Videos
Reliability and Validity
Lineage Commitment
In Vitro Drug Release Testing: Overview, Development and Validation
Predicting Molecular Geometry
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Hypertension III: Clinical Manifestations and Diagnostic Studies