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Retrospective Analysis of the Correlation between Uric Acid and Thyroid Hormone in People with Normal Thyroid
Guanqun Chao1, Yue Zhu1, Lizheng Fang1
1Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang University, China.
Journal of Diabetes Research
|July 31, 2019
Summary
This study found that uric acid levels are linearly correlated with thyroid hormones FT3 and FT4 in healthy adults. However, no significant correlation was observed between uric acid and thyroid-stimulating hormone (TSH).
Area of Science:
- Endocrinology
- Metabolic Health
- Clinical Chemistry
Background:
- Thyroid hormones regulate metabolism, and disruptions can lead to various health issues.
- Uric acid, a product of purine metabolism, has been implicated in several chronic conditions.
Purpose of the Study:
- To investigate the relationship between serum uric acid (SUA) levels and thyroid hormone profiles in a large cohort of healthy individuals.
- To clarify potential correlations between uric acid and thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4).
Main Methods:
- Retrospective analysis of general information and laboratory results from 48,526 healthy subjects who underwent physical examination.
- Serum uric acid (SUA) levels were categorized into quartiles for statistical comparison.
- Regression analyses were performed to assess the association between SUA and thyroid function parameters.
Main Results:
- Significant differences in TSH, FT3, and FT4 were observed across different SUA level groups.
- Serum uric acid showed a significant linear correlation with FT3 and FT4.
- No significant linear correlation was found between SUA and TSH.
Conclusions:
- In individuals with normal thyroid function, varying uric acid levels are associated with distinct TSH, FT3, and FT4 concentrations.
- Uric acid levels demonstrate a linear relationship with FT3 and FT4, suggesting a potential interplay between these metabolic markers.
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