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DNA ploidy in 1,2-dimethylhydrazine-induced rat tumors
1Department of Medicine, Institut Curie, Paris, France.
Japanese Journal of Cancer Research : Gann
|May 1, 1988
Abstract:
The DNA content of 1,2-dimethylhydrazine (DMH)-induced intestinal tumors of male Wistar rats was analyzed by using flow cytometry. All adenomas and carcinomas were DNA diploid. S-phase fractions of tumors showed no significant difference from those of normal mucosae. Histological evidence of adenoma-carcinoma sequence was observed in our series. The lack of DNA aneuploidy is one of the principal differences between the DMH model and human colorectal cancers.