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Irreversible oxidative post-translational modifications in heart disease.
Tamara Tomin1,2,3, Matthias Schittmayer1,2,3, Sophie Honeder1,2
1Institute of Pathology, Diagnostic and Research Center for Molecular Biomedicine, Medical University of Graz , Graz , Austria.
Expert Review of Proteomics
|July 31, 2019
Summary
Oxidative post-translational modifications are early indicators of cardiac damage, offering potential for novel heart failure biomarkers. These modifications precede acute conditions, aiding early diagnosis and treatment strategies.
Area of Science:
- Biochemistry
- Cardiology
- Biomarker Discovery
Background:
- Current heart failure biomarkers indicate acute conditions, not early disease stages.
- Oxidative stress and protein damage significantly worsen cardiac dysfunction.
- Oxidative post-translational modifications occur early in tissue damage, suggesting biomarker potential.
Purpose of the Study:
- To explore oxidative post-translational modifications as early diagnostic markers for heart failure.
- To review current clinical biomarkers and their limitations.
- To discuss the role of oxidative modifications in cardiac pathologies.
Main Methods:
- Summary of clinical practices for heart disease biomarkers.
- Discussion of various oxidative post-translational modifications in cardiac conditions.
- Analysis of quantitative techniques for detecting these modifications.
Main Results:
- Oxidative modifications are stable and analytically accessible markers.
- Irreversible oxidative modifications influence protein degradation and aggregation.
- Regulation of these modifications in the heart is crucial for biomarker abundance.
Conclusions:
- Oxidative post-translational modifications represent promising early biomarkers for heart failure.
- Understanding their regulation is key to developing new diagnostic tools.
- Further research into quantitative techniques will enhance their clinical utility.
Keywords:
Heart failureoxidative stresspost-translational modificationsprotein aggregationprotein degradationMore Related Videos
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