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Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure

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Oxidation-Sensitive Polymersomes Based on Amphiphilic Diblock Copolypeptoids.

Yangwei Deng^1,2, Hui Chen¹, Xinfeng Tao¹

¹Chimie ParisTech, PSL University Paris, CNRS, Institut de Recherche de Chimie Paris, UMR8247 , 11 rue Pierre et Marie Curie , 75005 Paris , France.

Biomacromolecules

|July 31, 2019

Summary

This summary is machine-generated.

New biocompatible polymersomes respond to oxidation, releasing cargo. These smart nanocontainers, made from biosourced copolypeptoids, offer controlled drug delivery and nano/microreactor applications.

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Area of Science:

Polymer Chemistry
Materials Science
Nanotechnology

Background:

Stimuli-responsive polymersomes are advanced drug delivery and nano/microreactor systems.
Amphiphilic block copolymers are key to creating these smart containers.
Oxidation-responsive materials offer unique control over vesicle function.

Purpose of the Study:

To develop novel, biosourced amphiphilic diblock copolypeptoids for self-assembly into oxidation-responsive polymersomes.
To investigate the stimuli-responsive behavior of these polymersomes, particularly their response to reactive oxygen species (ROS).
To evaluate the biocompatibility and potential applications of these novel polymersomes.

Main Methods:

Synthesis of poly(N-3-(methylthio)propyl glycine) as the hydrophobic block and polysarcosine (PSar) as the hydrophilic block.
Self-assembly of diblock copolypeptoids into unilamellar vesicles (polymersomes).
Investigation of vesicle response to ROS (hydrogen peroxide, singlet oxygen) and biocompatibility via cell viability tests.

Main Results:

Successfully synthesized and characterized novel amphiphilic diblock copolypeptoids.
Demonstrated self-assembly into oxidation-responsive unilamellar vesicles.
Confirmed vesicle bursting upon exposure to ROS, with potential for spatiotemporal control via photosensitizers.
Verified biocompatibility of the polymersomes through cell viability assays.

Conclusions:

Developed entirely N-substituted poly(amino acid)-based polymersomes with oxidation-responsive properties.
These biocompatible polymersomes show promise for applications in drug delivery, biosensing, biodetection, and nano/microreactors.
The thioether side chains in the hydrophobic block enable controlled oxidation and vesicle disassembly.