Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel case of combination antibiotic therapy for treatment of a complicated polymicrobial urinary tract infection with one organism harboring a metallo-β-lactamase (MBL) in a pregnant patient.

IDCases·2024
Same author

Hemolytic assay of the ninth complement component: elevation and depletion in rheumatic diseases.

The Journal of experimental medicine·2009
Same author

In vivo evaluation of matrix pellets containing nanocrystalline ketoprofen.

International journal of pharmaceutics·2002
Same author

An oral controlled release matrix pellet formulation containing nanocrystalline ketoprofen.

International journal of pharmaceutics·2001
Same author

Neutrophil chemotaxis and superoxide production are induced by cross-linking FcgammaRII receptors.

Cellular immunology·2000
Same author

Effect of allotype on activation of neutrophils by FcgammaRIIIB cross-linking.

Cellular immunology·2000
Same journal

Oral contraceptives: an update.

Hospital practice (Office ed.)·1995
Same journal

Progress in the immunogenetics of rheumatoid arthritis.

Hospital practice (Office ed.)·1995
Same journal

An asymptomatic lung nodule in an elderly woman with joint pain.

Hospital practice (Office ed.)·1995
Same journal

Defusing status epilepticus.

Hospital practice (Office ed.)·1995
Same journal

Persistent fever and flank discomfort in a young woman.

Hospital practice (Office ed.)·1995
Same journal

New thoughts on attention-deficit/hyperactivity disorder.

Hospital practice (Office ed.)·1995
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Hereditary angioedema. Undersuspected, underdiagnosed.

S Ruddy1

  • 1Medical College of Virginia, Richmond.

Hospital Practice (Office Ed.)
|August 15, 1988
PubMed
Summary
This summary is machine-generated.

Hereditary angioedema (HAE) is a rare but serious condition. Early diagnosis through C4 and C1 INH testing is crucial for preventing life-threatening complications and managing symptoms effectively.

More Related Videos

Surgical Treatment of an Endolymphatic Sac Tumor
04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

Related Experiment Videos

Last Updated: Jun 27, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Surgical Treatment of an Endolymphatic Sac Tumor
04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

Area of Science:

  • Immunology
  • Genetics
  • Plasma Protein Disorders

Background:

  • Hereditary angioedema (HAE) is an inherited deficiency of plasma proteins.
  • It is a rare cause of angioedema but relatively common among inherited protein deficiencies.

Observation:

  • Key diagnostic clues include upper respiratory obstruction, trauma-induced attacks, and abdominal pain.
  • Absence of a family history does not rule out HAE.

Findings:

  • C4 concentration measurement is a valuable screening test; normal levels exclude HAE.
  • Subnormal C4 necessitates C1 inhibitor (C1 INH) measurement via immunoassay or functional assay.
  • Functional assays are essential for identifying genetic variants of C1 INH.

Implications:

  • Accurate HAE diagnosis prevents severe complications like airway obstruction and unnecessary surgery.
  • Short-term prophylaxis can mitigate trauma-related complications.
  • Chronic treatment with attenuated androgens can suppress or eliminate symptoms in severely affected patients.