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Updated: Jan 21, 2026
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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
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Fecal microbiota transplantation for recurrent Clostridioides difficile infection
Stacy L Haber1, Carrington R K Raney2, Trent L Larson3
1Midwestern University College of Pharmacy-Glendale, Glendale, AZ.
Summary
Fecal microbiota transplantation (FMT) shows promising efficacy for recurrent Clostridioides difficile infection (CDI). Pharmacists play a key role in FMT delivery, from procurement to patient education, for managing recurrent CDI.
Area of Science:
- Gastroenterology
- Microbiology
- Pharmacology
Background:
- Recurrent Clostridioides difficile infection (CDI) poses a significant clinical challenge.
- Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic option for recurrent CDI.
Purpose of the Study:
- To review randomized controlled trials (RCTs) on the efficacy and safety of FMT for recurrent CDI.
- To discuss practical considerations for pharmacists involved in FMT delivery.
Main Methods:
- Analysis of eight RCTs evaluating FMT for recurrent CDI.
- Examination of variations in FMT preparation (fresh, frozen, lyophilized) and administration routes (nasogastric, colonoscopy, enema, oral).
Main Results:
- Efficacy rates for FMT in recurrent CDI ranged from 43.8% to 96.2%.
- Safety data across the analyzed trials were generally comparable.
- Pharmacists are integral to FMT delivery, including product procurement, documentation, administration, and patient education.
Conclusions:
- FMT is a viable treatment option for recurrent CDI, supported by RCT evidence.
- Optimal FMT delivery methods require further definition.
- Pharmacists are essential in the multidisciplinary management of patients with recurrent CDI undergoing FMT.
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