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The serotonergic system and the control of breathing during development
Kevin J Cummings1, Matthew R Hodges2
1Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA.
Respiratory Physiology & Neurobiology
|July 31, 2019
Summary
Serotonin (5-hydroxytryptamine, 5-HT) plays a crucial role in developing the brain
Area of Science:
- Neuroscience
- Developmental Biology
- Physiology
Background:
- Serotonin (5-hydroxytryptamine, 5-HT) discovered in the 1940s, has known roles in neurological function and behavior.
- Early research linked reduced brain 5-HT levels to clinical depression.
- Advances in molecular biology and physiology have deepened the understanding of 5-HT's multifaceted roles in development and adult neural function.
Purpose of the Study:
- To review the developmental roles of the serotonin (5-HT) system in the control of breathing.
- To examine the embryonic origins and fate specification of 5-HT neurons.
- To elucidate how the 5-HT system influences the maturation of the ventilatory control system and its relevance to respiratory pathologies.
Main Methods:
- Review of existing scientific literature on the serotonin system and respiratory control.
- Analysis of studies detailing embryonic development, neural maturation, and respiratory behaviors.
- Examination of research linking 5-HT system dysfunction to human respiratory disorders.
Main Results:
- The serotonin (5-HT) system is integral to the development and maturation of the ventilatory control system.
- 5-HT influences embryonic origins, fate specification of 5-HT neurons, and pre- and post-natal respiratory control.
- Dysfunction within the 5-HT system is implicated in respiratory pathologies such as Sudden Infant Death Syndrome (SIDS).
Conclusions:
- The serotonin (5-HT) system is critical for the proper development of respiratory control from embryonic stages through adulthood.
- Understanding the 5-HT system's role in breathing regulation is vital for addressing developmental respiratory disorders.
- Further research into the 5-HT system's influence on breathing may lead to new therapeutic strategies for conditions like SIDS.
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