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[11C]PIB PET imaging can detect white and grey matter demyelination in a non-human primate model of progressive

Robert H F Carvalho1, Caroline C Real1, Simone Cinini2

  • 1Laboratory of Nuclear Medicine (LIM-43), Departamento de Radiologia e Oncologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Multiple Sclerosis and Related Disorders
|July 31, 2019
PubMed
Abstract

Insights

Positron Emission Tomography (PET) with [11C]PIB effectively detects demyelination in both grey and white matter. This imaging technique shows promise for studying progressive multiple sclerosis (MS) in non-human primates.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Immunology

Background:

  • Multiple sclerosis (MS) is a central nervous system disease characterized by demyelination and inflammation.
  • Current diagnostic methods like MRI struggle to differentiate grey and white matter demyelination from inflammatory lesions.
  • Positron Emission Tomography (PET) with specific radiopharmaceuticals offers potential for distinguishing these pathological processes.

Purpose of the Study:

  • To evaluate [11C]PIB PET imaging as a tool for detecting demyelination.
  • To assess demyelinated regions in both white and grey matter.
  • To utilize a non-human primate model of progressive MS.

Main Methods:

  • Experimental autoimmune encephalomyelitis (EAE) induced in marmosets using recombinant human myelin oligodendrocyte glycoprotein (rhMOG).
  • Administration of rhMOG with Incomplete Freund's Adjuvant (IFA) or Complete Freund's Adjuvant (CFA).
  • [11C]PIB PET imaging performed at baseline and after symptom onset, followed by histochemical analysis.

Main Results:

  • Both rhMOG/IFA and rhMOG/CFA induced EAE.
  • Significant [11C]PIB uptake reduction observed in various brain regions, particularly in the rhMOG/IFA group.
  • [11C]PIB uptake correlated strongly with luxol fast blue histology, a myelin marker.

Conclusions:

  • [11C]PIB PET imaging demonstrates efficacy in identifying demyelination.
  • The technique is suitable for both grey and white matter.
  • [11C]PIB PET is a valuable tool for studying progressive MS models.
Keywords:
EAE marmoset modelMultiple sclerosisPET imagingPittsburgh compound B

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