Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Evolutionary History?02:35

What is Evolutionary History?

42.9K
Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
42.9K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.8K
Evolutionary Psychology01:20

Evolutionary Psychology

958
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
958
What is Natural Selection?01:32

What is Natural Selection?

126.0K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
126.0K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

346
In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
346
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.9K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: The dynamics of mutational selection in cutaneous squamous carcinogenesis.

Communications biology·2026
Same author

An estrogen receptor/E2F1/CDKN3 axis protects from UV-induced skin cancers in females.

EMBO reports·2026
Same author

The dynamics of mutational selection in cutaneous squamous carcinogenesis.

Communications biology·2026
Same author

Low-input proteomics identifies vWF as a negative regulator of Tet2 mutant hematopoietic stem cell expansion.

Cell reports·2025
Same author

The pathogenesis of therapy-related myeloid neoplasms from TP53-mutant clonal hematopoiesis.

Leukemia·2025
Same author

OmniPath: integrated knowledgebase for multi-omics analysis.

Nucleic acids research·2025
Same journal

RNA-ligand complexes and the attenuation of neutral confinement in the evolution of RNA secondary structures.

Journal of the Royal Society, Interface·2026
Same journal

Individual detachment-reintegration events in homing pigeon flocks and the dominance of directional adjustment in their kinematic features.

Journal of the Royal Society, Interface·2026
Same journal

Thermal stress disrupts symbiotic fluid dynamics in bobtail squid.

Journal of the Royal Society, Interface·2026
Same journal

Distinct geometrical landscapes distinguish between modes of tristability in gene regulatory networks.

Journal of the Royal Society, Interface·2026
Same journal

Slow modulation of the contraction patterns in Physarum polycephalum.

Journal of the Royal Society, Interface·2026
Same journal

Moo-ving mountains: grazing agents drive terracette formation on steep hillslopes.

Journal of the Royal Society, Interface·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

10.0K

Relating evolutionary selection and mutant clonal dynamics in normal epithelia.

Michael W J Hall1,2, Philip H Jones1,2, Benjamin A Hall2

  • 1Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

Journal of the Royal Society, Interface
|August 1, 2019
PubMed
Summary
This summary is machine-generated.

Somatic mutations in normal tissues may not affect cell fate, but this can be masked by experimental factors. Properly designed studies can reveal non-neutral competition, crucial for understanding cancer risk.

Keywords:
DNA sequencingcanceroesophagusstem cells

More Related Videos

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia
08:25

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia

Published on: August 8, 2013

21.6K
Gene-targeted Random Mutagenesis to Select Heterochromatin-destabilizing Proteasome Mutants in Fission Yeast
07:18

Gene-targeted Random Mutagenesis to Select Heterochromatin-destabilizing Proteasome Mutants in Fission Yeast

Published on: May 15, 2018

11.1K

Related Experiment Videos

Last Updated: Jan 21, 2026

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
08:25

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

10.0K
Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia
08:25

Ex vivo Method for High Resolution Imaging of Cilia Motility in Rodent Airway Epithelia

Published on: August 8, 2013

21.6K
Gene-targeted Random Mutagenesis to Select Heterochromatin-destabilizing Proteasome Mutants in Fission Yeast
07:18

Gene-targeted Random Mutagenesis to Select Heterochromatin-destabilizing Proteasome Mutants in Fission Yeast

Published on: May 15, 2018

11.1K

Area of Science:

  • Cell Biology
  • Genetics
  • Cancer Research

Background:

  • Cancer arises from mutated cells within normal tissues.
  • Understanding how somatic mutations influence normal cell dynamics is critical for cancer risk assessment and prevention strategies.

Purpose of the Study:

  • To investigate whether somatic mutations alter normal cell dynamics and clonal expansion.
  • To re-evaluate the interpretation of clone size distributions in the context of neutral drift versus positive selection.
  • To identify factors that can obscure non-neutral behavior in experimental data.

Main Methods:

  • Analysis of the first incomplete moment of clone size distributions in human eyelid skin.
  • Incorporation of constraints on clone growth, including compartment size and cell competition.
  • Validation using a new experimental dataset with appropriately designed experiments.

Main Results:

  • Initial analyses suggested neutral drift, implying mutations do not affect cell fate.
  • This conflicts with genetic evidence indicating strong positive selection for certain mutations.
  • Accounting for epithelial constraints revealed that the first incomplete moment cannot exclude non-neutral behavior.
  • Experimental artifacts can lead to neutral-appearing distributions from non-neutral clones.

Conclusions:

  • The first incomplete moment of clone size distributions can be misleading regarding neutral drift.
  • Experimental design is crucial for accurately assessing clonal competition and selection.
  • Properly designed experiments confirm the utility of the first incomplete moment in detecting non-neutral competition.