Related Experiment Video

Updated: Jan 21, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.9K

Mild Parkinsonian Signs in a Hospital-based Cohort of Mild Cognitive Impairment Types: A Cross-sectional Study

Cecilia Camarda1, Paola Torelli2, Carmela Pipia3

  • 1Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Palermo, Italy.

Current Alzheimer Research
|August 1, 2019
PubMed
Abstract

Insights

Mild Parkinsonian Signs (MPS) are common in Mild Cognitive Impairment (MCI) and linked to brain changes like white matter hyperintensities and atrophy. These signs may indicate increased risk for dementia progression.

Area of Science:

  • Neurology
  • Neuroimaging
  • Geriatrics

Background:

  • Mild Parkinsonian Signs (MPS) have shown conflicting associations with Mild Cognitive Impairment (MCI) subtypes.
  • Understanding this relationship is crucial for early diagnosis and intervention in cognitive decline.

Purpose of the Study:

  • To investigate the association between individual MPS and different MCI types.
  • To evaluate the link between MPS and specific neuroimaging markers including caudate atrophy, global cerebral atrophy, White Matter Hyperintensities (WMH), and lacunes in MCI patients.

Main Methods:

  • A cross-sectional study of 1,168 MCI patients (aged 45-97) utilizing brain MRI.
  • Assessment of MPS using the Unified Parkinson's Disease Rating Scale motor section (tremor, rigidity, bradykinesia, gait/balance/axial dysfunction).
  • Evaluation of WMH, lacunes, caudate atrophy (bicaudate ratio), and global cerebral atrophy (ventricles to brain ratio). Apolipoprotein E (APOE) genotyping was also performed.

Main Results:

  • Bradykinesia and gait/balance/axial dysfunction were the most frequent MPS observed.
  • MPS were present in both amnestic and non-amnestic MCI subtypes.
  • MPS were significantly associated with WMH, lacunes, caudate atrophy, and global cerebral atrophy.

Conclusions:

  • MPS are prevalent in both amnestic and non-amnestic MCI, especially in multiple-domain MCI and in individuals with the APOE ε4 allele.
  • Vascular and atrophic brain processes (cortical and subcortical) contribute to the development of MPS in MCI.
  • Further longitudinal studies are necessary to clarify the role of MPS in the progression from MCI to dementia.
Keywords:
Mild parkinsonian signscaudate atrophyglobal cerebral atrophylacunesmild cognitive impairment typeswhite matter hyperintensities.

More Related Videos

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

5.0K
Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

9.7K

Related Concept Videos

Cross-Sectional Research01:50

Cross-Sectional Research

In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
12.4K
Hospitals-II00:59

Hospitals-II

Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in...
1.1K
Profile Leveling and Cross Sections01:26

Profile Leveling and Cross Sections

Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes.  Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
1.6K
Hospitals-I01:28

Hospitals-I

Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
1.5K
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
4.4K
Cognitive Dissonance01:38

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
36.8K