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Potential Drug Targets Against Hepatitis B Virus Based on Both Virus and Host Factors

Bing-Yi Zhang1, Dan-Ping Chai1, Yi-Hang Wu1

  • 1Department of Pharmacy, Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou 310018, China.

Current Drug Targets
|August 1, 2019
PubMed

Insights

Discovering new hepatitis B virus (HBV) drug targets is crucial due to existing treatment limitations and drug resistance. This review summarizes viral, host, and immune targets for developing innovative HBV therapies.

Area of Science:

  • Hepatology
  • Virology
  • Drug Discovery

Background:

  • Hepatitis B virus (HBV) infection remains a significant global health burden despite available vaccines.
  • Current treatments like nucleoside analogues and interferon-alpha have limitations, including drug resistance due to HBV genome variability.
  • There is an urgent need for novel therapeutic strategies and drugs to effectively cure chronic hepatitis B.

Purpose of the Study:

  • To provide theoretical support for the development of innovative anti-HBV drugs.
  • To summarize current antiviral targets against hepatitis B virus infection.
  • To guide the design of new therapeutic agents by reviewing potential targets.

Main Methods:

  • Analysis of advances in potential drug targets for anti-HBV infection.
  • Focus on targeting the virus genome, host cellular functions, and virus-host protein interactions.
  • Emphasis on immune targets against chronic hepatitis B.

Main Results:

  • HBV, an obligate intracellular parasite, relies on host cell machinery for replication.
  • Targeting both viral and host factors presents a promising therapeutic approach.
  • A comprehensive summary of antiviral strategies targeting viral, host, and immune factors is presented.

Conclusions:

  • The review offers a summary of antiviral therapeutic strategies for HBV infection.
  • It highlights the importance of targeting virus, host, and immune factors for future drug design.
  • This work supports the development of innovative drugs against HBV.
Abstract

Keywords:
Hepatitis B virusdrug designhost targetimmune targetviral targetvirus-host interactions.

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