Related Experiment Video
Updated: Jan 21, 2026
10:10
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
9.2K
Leptin and Its Derivatives: A Potential Target for Autoimmune Diseases
1Department of Biochemistry and Molecular Biology, Shenyang Medical College, No.146 North Huanghe St. Huanggu Dis, Shenyang City, Liaoning Pro 110034, China.
Current Drug Targets
|August 1, 2019
Summary
Leptin, a hormone from fat cells, modulates immune responses and inflammation. Its role in immune cell function and inflammatory markers suggests potential as a therapeutic target for autoimmune diseases.
Area of Science:
- Immunology and Endocrinology
- Metabolic and Inflammatory Diseases
Background:
- Leptin is an adipocyte-derived hormone crucial for immune homeostasis.
- Its immunomodulatory functions in inflammatory and immune responses are gaining attention.
Purpose of the Study:
- To review the multifaceted roles of leptin in immune regulation.
- To explore leptin's potential as a therapeutic target for autoimmune diseases.
Main Methods:
- Literature review focusing on leptin's effects on immune cells and inflammatory markers.
- Analysis of leptin's involvement in metabolism, cellular development, and hematopoiesis.
Main Results:
- Leptin modulates monocytes, dendritic cells, neutrophils, NK cells, T cells, and B cells.
- Elevated leptin influences secretion of IL-6, C-reactive protein, and TNF-α.
- Leptin is implicated in metabolism, inflammation, cellular development, and hematopoiesis.
Conclusions:
- Leptin is a key regulator of immune and inflammatory processes.
- Its diverse functions highlight its potential for therapeutic development in autoimmune conditions.
Related Concept Videos
01:29Autoimmune Disorders
1.5K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.5K
02:58Cell Potential and Free Energy
46.3K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.3K
00:52Potential Energy
42.3K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.3K
01:09Potential Energy
980
A conservative force, such as a gravitational or elastic force, gives the body the capacity to do work. This capacity, measured as the potential energy, depends on the body's location or “position” relative to a fixed reference position or datum. The gravitational potential energy is considered zero at the reference point. Suppose a body is located at some vertical distance above a fixed horizontal reference or datum. In that case, the weight of the body has positive gravitational potential...
980
03:02Standard Electrode Potentials
50.0K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.0K
01:21The Resting Membrane Potential
142.0K
Overview
142.0K