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Updated: Jan 21, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
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Effect of Levetiracetam on Cognitive Function and Clonic Seizure Frequency in Children with Epilepsy

Shihao Zhou1, Qiong Zhan2, Xiaomei Wu2

  • 1Department of Genetic and Eugenics,Changsha Hospital for Maternal and Child Health Care, Changsha, Hunan, 410011, China.

Current Molecular Medicine
|August 1, 2019
PubMed

Insights

Levetiracetam effectively treats childhood epilepsy by improving cognitive function and reducing seizure frequency. This epilepsy medication shows significant promise for young patients.

Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology

Background:

  • Epilepsy affects numerous children worldwide, necessitating effective treatment options.
  • Current treatments for childhood epilepsy present challenges, including variable efficacy and side effects.

Purpose of the Study:

  • To evaluate the clinical efficacy of levetiracetam compared to conventional valproate therapy in children with epilepsy.
  • To assess the impact of levetiracetam on cognitive function and seizure frequency in pediatric epilepsy patients.

Main Methods:

  • A randomized controlled trial involving 136 children with epilepsy.
  • Patients were assigned to either levetiracetam (experimental group) or valproate (conventional group).
  • Outcomes measured included overall effective rate, cognitive function scores, and seizure frequency.

Main Results:

  • Levetiracetam demonstrated significantly improved cognitive functions, including attention and executive ability, compared to valproate.
  • The frequency of myoclonic and tonic-clonic seizures was significantly reduced with levetiracetam treatment.
  • No significant difference was observed in the overall effective rate between the two treatment groups.

Conclusions:

  • Levetiracetam is an effective treatment for childhood epilepsy.
  • Levetiracetam offers benefits in enhancing cognitive function and reducing seizure frequency in pediatric patients.
  • The findings suggest levetiracetam has high potential for clinical application in treating childhood epilepsy.
Abstract

Keywords:
Epilepsyclonic seizurecognitive functionlevetiracetammyoclonic seizures.

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