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Related Concept Videos

Areas Within Irregular Boundaries01:26

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Calculating areas within irregular boundaries, such as along rivers or curved roads, is crucial in various fields, including surveying, engineering, and environmental management. Surveyors often begin by creating a traverse, a connected series of straight lines approximating the area's boundary. The coordinates of each traverse point are essential for calculating the enclosed area. The double meridian distance formula is a widely used technique for this purpose. This method utilizes the...
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Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
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An electrocardiogram (ECG)graphically represents the heart's electrical activity on ECG paper or a monitor.
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EEG Mu Rhythm in Typical and Atypical Development
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An irregular, extremely broad QRS complex rhythm.

Adriaan Wilgenhof1, Vincent Michiels1, Bernard Cosyns1

  • 1Department of cardiology, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.

The American Journal of Emergency Medicine
|August 1, 2019
PubMed
Summary
This summary is machine-generated.

Flecainide intoxication can cause dangerous QRS widening, especially with acute renal failure. Prompt treatment with sodium bicarbonate effectively reversed these critical electrocardiogram changes.

Keywords:
Acute renal failureBroad QRS complexDrug toxicityFlecainide

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Area of Science:

  • Cardiology
  • Clinical Toxicology
  • Pharmacology

Background:

  • Flecainide is a Class Ic antiarrhythmic agent.
  • Acute renal failure can impair flecainide clearance, increasing toxicity risk.
  • Wide QRS complex on electrocardiogram (ECG) is a hallmark of flecainide toxicity.

Observation:

  • A 74-year-old female presented with a significantly widened QRS complex.
  • The patient's presentation was attributed to flecainide intoxication secondary to acute renal failure.

Findings:

  • Prompt recognition of ECG abnormalities and clinical symptoms was crucial.
  • Intravenous administration of high-dose sodium bicarbonate was initiated as a targeted treatment.

Implications:

  • Sodium bicarbonate effectively corrected the QRS widening, indicating successful management.
  • This case highlights the importance of considering drug toxicity in patients with renal impairment and ECG changes.
  • Early intervention with sodium bicarbonate is a vital strategy for managing flecainide-induced cardiotoxicity.