Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Ras Gene

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...

Small GTPases - Ras and Rho

Small GTPases - Ras and Rho

Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.

Predator-Prey Interactions

Predator-Prey Interactions

Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.

Functional Groups

Functional Groups

Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...

Functional Groups

Functional Groups

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The phage nucleus synergizes with an anti-defense protein to resist bacterial immunity.

Cell reports·2026

Same author

In Support of Venous Glucose as a Reference Matrix for Evaluating Continuous Glucose Monitoring Accuracy.

Journal of diabetes science and technology·2026

Same author

Nucleus-forming phages: from subcellular organization and viral-host interplay to prospects for phage applications.

Current opinion in microbiology·2025

Same author

KSR1 is a scaffold for the Hippo signaling pathway.

Communications biology·2025

Same author

Phage Therapy for Urinary Tract Infections: Progress and Challenges Ahead.

International urogynecology journal·2025

Same author

Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection.

Cell host & microbe·2025

Same journal

Application of ephrin-B2 loaded glycol chitosan-silk fibroin hydrogel in the treatment of diabetic refractory wounds.

Scientific reports·2026

Same journal

International expert Delphi consensus on thromboprophylaxis in metabolic and bariatric surgery.

Scientific reports·2026

Same journal

Assessing the cross-region knowledge transfer capability of selected deep learning building vectorization methods in the context of available training datasets.

Scientific reports·2026

Same journal

Feasibility and preliminary effects of outdoor versus indoor cognitive-motor therapy in women with Alzheimer's disease: A randomized single-blind pilot study.

Scientific reports·2026

Same journal

Hallmarks of social action in the vocal turn-taking of wild common marmosets (Callithrix jacchus).

Scientific reports·2026

Same journal

Role and mechanism of AOPPs-induced NOX4-mediated ferroptosis in intervertebral disc degeneration.

Scientific reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 21, 2026

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Published on: October 5, 2020

Endogenous IQGAP1 and IQGAP3 do not functionally interact with Ras.

Chase J Morgan¹, Andrew C Hedman¹, Zhigang Li¹

¹From the Department of Laboratory Medicine, National Institutes of Health, 10 Center Drive, Bethesda, Maryland, 20892, USA.

Scientific Reports

|August 1, 2019

Summary

This summary is machine-generated.

This study found no evidence that IQGAP1 or IQGAP3 proteins interact with Ras proteins (H-, K-, or N-Ras). These findings challenge the development of therapies targeting Ras-IQGAP interactions for cancer treatment.

More Related Videos

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays

Published on: October 20, 2023

Functional Characterization of Endogenously Expressed Human RYR1 Variants

Functional Characterization of Endogenously Expressed Human RYR1 Variants

Published on: June 9, 2021

Related Experiment Videos

Last Updated: Jan 21, 2026

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Published on: October 5, 2020

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays

Published on: October 20, 2023

Functional Characterization of Endogenously Expressed Human RYR1 Variants

Functional Characterization of Endogenously Expressed Human RYR1 Variants

Published on: June 9, 2021

Area of Science:

Molecular biology
Cell signaling
Cancer research

Background:

Ras GTPases are crucial for cell processes, and their mutations drive cancer.
IQGAP proteins regulate signaling molecules, including Rho GTPases.
Previous studies conflict on whether IQGAP proteins bind to Ras proteins.

Purpose of the Study:

To resolve conflicting data regarding IQGAP and Ras protein interactions.
To investigate the functional relevance of potential Ras-IQGAP associations.

Main Methods:

Investigated binding of endogenous IQGAP1 and IQGAP3 to H-, K-, and N-Ras.
Assessed the effect of IQGAP1 or IQGAP3 depletion on Ras activation by epidermal growth factor.

Main Results:

Neither IQGAP1 nor IQGAP3 were found to bind to endogenous H-, K-, or N-Ras.
Depletion of IQGAP1 or IQGAP3 did not alter Ras activation by epidermal growth factor.

Conclusions:

IQGAP proteins do not appear to be functional interactors of H-, K-, or N-Ras.
Targeting Ras-IQGAP interactions for cancer therapy may not be a viable strategy.