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Progress in trial registration in Latin America and the Caribbean, 2007-2013
Pablo Rodríguez-Feria1, Luis Gabriel Cuervo1
1Office of Knowledge Management, Bioethics, and Research Pan American Health Organization (PAHO) / Regional Office of the World Health Organization (WHO) Washington, DC United States of America Office of Knowledge Management, Bioethics, and Research, Pan American Health Organization (PAHO) / Regional Office of the World Health Organization (WHO), Washington, DC, United States of America.
Abstract:
This descriptive study identifies trends in clinical trial registration in the World Health Organization International Clinical Trial Registry Platform (ICTRP) for Latin America and the Caribbean (LAC), from 2007-2013, and provides adjusted estimates for registration rates by population and publications (2007-2011). Trends and data are presented by subregion and language in interactive graphs, including annual registration rates by population (2007-2011) and publications (LILACS and MEDLINE) listed in SCIENTI Network (Science and Technology Indicators). Of the 11 945 clinical trials involving LAC countries, 8 282 were in South America, with Brazil leading at 4 070 (49%); 2 421 in North and Central America, with Mexico leading at 1 886 (78%); and 1 242 in the Caribbean, with Puerto Rico leading at 857 (69%). After adjusting by population and publication rates Chile, Panama, Argentina, and Peru led registration rates per 1 million inhabitants. Variations in the number of trials per year are quite substantial. Clinical trial registration increased in a steady yet inconsistent way. The implementation of the Policy on Research for Health has been followed by an increase in countries that require registration and have established clinical trial registries. However, there is room for improvement in adherence throughout LAC. Trial registration is offered gratis by Brazilian, Cuban, Peruvian, and United States registries, among others.
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