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Related Experiment Video

Updated: Jan 21, 2026

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Relationship between circulating irisin levels and overweight/obesity: A meta-analysis.

Jue Jia1, Fan Yu2, Wei-Ping Wei2

  • 1Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China. 1000011436@ujs.edu.cn.

World Journal of Clinical Cases
|August 1, 2019
PubMed
Summary

This meta-analysis found higher circulating irisin levels in overweight and obese individuals compared to healthy controls. These findings highlight irisin

Keywords:
Body mass indexIrisinMyokinesOverweight/obesity

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Area of Science:

  • Endocrinology and Metabolism
  • Obesity Research
  • Myokine Function

Background:

  • Irisin, a novel myokine, has shown inconsistent associations with obesity in previous studies.
  • A comprehensive analysis was lacking to clarify the relationship between irisin levels and overweight/obesity.
  • Understanding irisin's role is crucial for developing strategies to combat the growing obesity epidemic.

Purpose of the Study:

  • To systematically evaluate the association between circulating irisin levels and the condition of overweight/obesity.
  • To synthesize existing evidence through meta-analysis to provide a robust conclusion on irisin and obesity.
  • To explore potential variations in this association across different ethnic groups and age demographics.

Main Methods:

  • A systematic literature search was conducted across major databases: Cochrane Library, MEDLINE, SCOPUS, and Web of Science.
  • Studies investigating circulating irisin levels in relation to overweight/obesity were identified and included.
  • Meta-analysis methodology was employed to pool data, calculating standard mean differences and 95% confidence intervals.

Main Results:

  • The meta-analysis included 18 studies with 1005 cases and 1242 controls.
  • Overall, overweight/obese individuals exhibited significantly higher circulating irisin levels compared to healthy controls (MD = 0.63, P = 0.003).
  • Subgroup analyses revealed elevated irisin in African overweight/obese populations and in obese children, but not consistently across other ethnicities or age groups.

Conclusions:

  • This meta-analysis provides strong evidence that circulating irisin levels are elevated in individuals with obesity.
  • The findings underscore the potential role of irisin as a biomarker in the context of overweight and obesity.
  • Further research is warranted to elucidate the specific mechanisms and ethnic variations in the irisin-obesity relationship.