Related Experiment Video
Updated: Jan 21, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
Published on: March 10, 2021
Genome-Based Bioinformatic Prediction of Major Histocompatibility (MHC)
1Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, ON, Canada. simon.foote@nrc-cnrc.gc.ca.
Abstract:
Over the last 17 years, a large amount of knowledge has been accumulated on various aspects of major histocompatibility complex (MHC) molecules. In conjunction, numerous algorithms and tools have been developed to screen protein molecules for these MHC receptor sites. By combining these computational tools and databases with genomic sequence information that is now widely available for a vast range of organisms, it is possible to screen whole genomes for MHC epitopes. By pre-screening these genomes, it allows the researcher to narrow down possible protein targets for further analysis by traditional tools such as gene knockouts and animal efficacy studies.
Related Concept Videos
Genomics
Predicting Molecular Geometry
Major Organs of the Digestive System
Gastrointestinal tract:
Major Losses in Pipes
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Genome Size and the Evolution of New Genes

