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Chemistry is an empirical science. Scientists often pose questions to understand the chemistry in everyday life and seek answers to these questions. To achieve this, scientists follow a definitive series of steps that together make up the Scientific Method. This approach involves making observations, asking questions, building a hypothesis, conducting experiments, analyzing results, and forming a conclusion. 
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Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
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Conclusion.

Roger L Nation1

  • 1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville Campus, Melbourne, VIC, Australia. roger.nation@monash.edu.

Advances in Experimental Medicine and Biology
|August 1, 2019
PubMed
Summary
This summary is machine-generated.

Polymyxins, last-line antibiotics, have seen renewed understanding of their chemical, microbiological, and pharmacological properties. International conferences have led to redevelopment frameworks and optimal use guidelines for these critical drugs.

Keywords:
ColistinConsensus statements and guidelinesPolymyxin BPolymyxinsProgress in understanding how to use in patients

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Area of Science:

  • Pharmacology
  • Microbiology
  • Medicinal Chemistry

Background:

  • Polymyxins, crucial last-line antibiotics, were reintroduced into clinical practice early in the 21st century.
  • Significant advancements in understanding their properties have occurred since their resurgence.

Purpose of the Study:

  • To review progress in the chemical, microbiological, and pharmacological understanding of polymyxins.
  • To discuss outcomes from international conferences on polymyxin research and application.

Main Methods:

  • Literature review of polymyxin research.
  • Analysis of key outcomes from three international polymyxin conferences.

Main Results:

  • Progress in understanding polymyxin chemical, microbiological, and pharmacological characteristics.
  • Publication of a consensus statement for polymyxin redevelopment.
  • Development of international consensus guidelines for optimal polymyxin patient use.

Conclusions:

  • The resurrection of polymyxins has been accompanied by substantial scientific progress.
  • International collaboration has yielded frameworks for antibiotic redevelopment and clinical use guidelines.