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Psychotic symptoms following oxycodone withdrawal, case report and update
N M Casado-Espada1, C Martín, J I De La Iglesia-Larrad
1University of Salamanca Healthcare Complex, Psychiatry Service, Salamanca, Spain. croncero@saludcastillayleon.es.
European Review for Medical and Pharmacological Sciences
|August 1, 2019
Summary
Opiate withdrawal can trigger psychosis, even in individuals without prior psychiatric history. This case highlights oxycodone withdrawal as a potential cause of temporary psychotic symptoms, managed with antipsychotic medication.
Area of Science:
- Psychiatry
- Neurology
- Pharmacology
Background:
- Opiate withdrawal-induced psychosis is a rare clinical event.
- Chronic pain patients on analgesics, including oxycodone, are susceptible.
- No prior psychiatric history in the presented case.
Observation:
- A 36-year-old male developed delusions, hallucinations, and aberrant behavior.
- Symptoms emerged after abrupt cessation of prescribed oxycodone.
- Psychotic episodes fluctuated, alternating between lucid and delusional states.
Findings:
- Oxycodone withdrawal was strongly associated with the onset of psychotic symptoms.
- Antipsychotic medication effectively resolved the symptomatology.
- The case underscores the link between opioid cessation and psychosis.
Implications:
- Highlights the importance of considering opioid withdrawal in new-onset psychosis.
- Suggests careful management of opioid analgesics in chronic pain patients.
- Informs differential diagnosis and treatment strategies for opioid-associated psychiatric disturbances.
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