[Corynebacterium group D2. Clinical study, biochemical identification and antibiotic sensitivity]

Area of Science:

• Clinical Microbiology
• Infectious Diseases
• Antimicrobial Resistance

Background:

• Corynebacterium group D2 is increasingly recognized for its role in urinary tract infections (UTIs), often associated with urinary stones.
• These bacteria exhibit opportunistic behavior, becoming pathogenic in non-urinary sites, particularly in immunosuppressed individuals.

Purpose of the Study:

• To investigate the pathogenic role of Corynebacterium group D2 in UTIs.
• To evaluate rapid identification methods and antibiotic susceptibility patterns.
• To determine effective therapeutic agents for infections caused by this pathogen.

Main Methods:

• Comparative study of 44 urine isolates of Corynebacterium group D2.
• Utilized rapid tests including urease, glucose acidification, and nitrate reductase assays.
• Antibiotic susceptibility testing, including Minimum Inhibitory Concentration (MIC) determination for 10 antibiotics.

Main Results:

• Corynebacterium group D2 was frequently identified as a pathogen in UTIs.
• Rapid tests combined with antibiotic resistance patterns aided in easy identification.
• Vancomycin and pristinamycin demonstrated 100% sensitivity (MIC modes: 0.5 and 0.03 mg/l, respectively) for non-urinary infections.
• Ciprofloxacin and ofloxacin showed significant activity against urinary isolates (MIC modes: 4 and 2 mg/l).

Conclusions:

• Corynebacterium group D2 plays a significant role in UTIs and can be opportunistic.
• Rapid diagnostic methods and antibiotic resistance profiling are crucial for identification.
• Vancomycin and pristinamycin are recommended for non-urinary infections, while ciprofloxacin and ofloxacin are viable options for UTIs caused by Corynebacterium group D2.