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Related Concept Videos

Tight Junctions01:29

Tight Junctions

7.0K
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
7.0K
P-N junction01:11

P-N junction

1.1K
A p-n junction is formed when p-type and n-type semiconductor materials are joined together. At the interface of the p-n junction, holes from the p-side and electrons from the n-side begin to diffuse into the opposite sides due to the concentration gradient. This diffusion of carriers leads to a region around the junction where there are no free charge carriers, known as the depletion region. The charge density within the depletion region for the n-side and p-side can be described by the...
1.1K
Impact of Groups on Groups01:19

Impact of Groups on Groups

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Social psychologists analyze how groups influence one another, shaping social structures and interactions through both cooperation and competition. These dynamics manifest in various ways, ranging from economic partnerships to intergroup conflicts that shape societal structures and perceptions.Cooperation and Competition in Intergroup RelationsIntergroup relationships vary across contexts, sometimes fostering cooperation and mutual benefit while at other times leading to conflict and...
236
The Neuromuscular Junction01:19

The Neuromuscular Junction

18.2K
The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
18.2K
Anchoring Junctions01:03

Anchoring Junctions

4.9K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
4.9K
Adherens Junctions01:24

Adherens Junctions

6.2K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Updated: Jan 21, 2026

Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands
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Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands

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Biomaterial-tight junction interaction and potential impacts.

Xiangfei Han1, Ershuai Zhang1, Yuanjie Shi1

  • 1Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, Michigan 48202, USA. zcao@wayne.edu.

Journal of Materials Chemistry. B
|August 1, 2019
PubMed
Summary
This summary is machine-generated.

Biomaterials can open epithelial tight junctions (TJs) to enhance drug delivery, but understanding these interactions is crucial. This review explores TJ structure, biomaterial effects, and risks like infection and autoimmunity.

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Area of Science:

  • Pharmacology and Drug Delivery
  • Biomaterials Science
  • Cell Biology

Background:

  • Epithelial tight junctions (TJs) are critical barriers controlling paracellular transport of hydrophilic drugs, including peptides and proteins.
  • Biomaterials offer potential for opening TJs to improve oral bioavailability and drug targeting efficacy.
  • Current understanding of biomaterial-TJ interactions remains limited, with potential risks of infection and autoimmunity.

Purpose of the Study:

  • To review the current literature on the structure and function of epithelial tight junctions (TJs).
  • To elucidate the mechanisms by which biomaterials interact with TJs.
  • To discuss the benefits and drawbacks of TJ disruption for drug delivery and associated risks.

Main Methods:

  • Comprehensive literature search of peer-reviewed articles on TJs, biomaterials, and drug delivery.
  • Analysis of studies detailing TJ structure and paracellular transport mechanisms.
  • Review of research on biomaterial-TJ interactions, including mechanisms and consequences.

Main Results:

  • TJs regulate the passage of hydrophilic drugs, with peptides and proteins being particularly affected.
  • Various biomaterials demonstrate the ability to modulate TJ permeability.
  • Disruption of TJs by biomaterials presents both opportunities for enhanced drug delivery and risks.

Conclusions:

  • Further research is needed to fully understand biomaterial-TJ interactions for safe and effective drug delivery.
  • Balancing enhanced drug transport with the integrity of epithelial barriers is essential.
  • Developing methods to evaluate these interactions is critical for therapeutic applications.